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Marlborough, Massachusetts–(Newsfile Corp. – December 19, 2024) – Phio Pharmaceuticals Corp. (NASDAQ: PHIO), a clinical-stage biotechnology company that develops therapeutics using its INTASYL® siRNA gene silencing technology to make the body’s immune cells more effective in killing cancer cells, today announced that it has entered into definitive agreements for the purchase and sale of an aggregate of 437,192 shares of its common stock at a purchase price of $2.635 per share in a registered direct offering priced at-the-market under Nasdaq rules. In addition, in a concurrent private placement, the Company will issue unregistered warrants to purchase up to 437,192 shares of common stock. The warrants will have an exercise price of $2.51 per share, will be exercisable upon issuance and expire five years following the date of issuance. The closing of the offering is expected to occur on or about December 20, 2024, subject to the satisfaction of customary closing conditions. H.C. Wainwright & Co. is acting as the exclusive placement agent for the offering. The aggregate gross proceeds to the Company from the offering are expected to be approximately $1.15 million, before deducting the placement agent fees and other offering expenses payable by the Company. The Company currently intends to use the net proceeds from the offering for working capital and other general corporate purposes. The shares of common stock (but not the warrants issued in the private placement or the shares of common stock underlying such warrants) are being offered by the Company pursuant to a “shelf” registration statement on Form S-3 (File No. 333-279557) filed with the Securities and Exchange Commission (“SEC”) on May 20, 2024 and became effective on July 1, 2024. The registered direct offering of the shares of common stock is being made only by means of a prospectus, including a prospectus supplement, forming a part of the effective registration statement. The prospectus supplement and the accompanying prospectus relating to the shares of common stock being offered in the registered direct offering will be filed with the SEC and be available at the SEC’s website at www.sec.gov . Electronic copies of the prospectus supplement and the accompanying prospectus relating to the registered direct offering may also be obtained, when available, by contacting H.C. Wainwright & Co., LLC at 430 Park Avenue, 3rd Floor, New York, NY 10022, by telephone at (212) 856-5711 or e-mail at placements@hcwco.com . The warrants described above are being issued in a concurrent private placement under Section 4(a)(2) of the Securities Act of 1933, as amended (the “Securities Act”), and Regulation D promulgated thereunder and, along with the shares of common stock underlying the warrants, have not been registered under the Securities Act, or applicable state securities laws. Accordingly, the warrants and underlying shares of common stock may not be offered or sold in the United States except pursuant to an effective registration statement or an applicable exemption from the registration requirements of the Securities Act and such applicable state securities laws. This press release shall not constitute an offer to sell or the solicitation of an offer to buy any of the securities described herein, nor shall there be any sale of these securities in any state or jurisdiction in which such offer, solicitation or sale would be unlawful prior to the registration or qualification under the securities laws of any such state or jurisdiction. About Phio Pharmaceuticals Corp. Phio Pharmaceuticals Corp. (NASDAQ: PHIO) is a clinical-stage biotechnology company advancing its proprietary INTASYL siRNA gene silencing technology to eliminate cancer. INTASYL can target and silence virtually any gene with high degree of specificity across a wide range of cell types and tissues. INTASYL is designed to enhance the ability of immune cells to more effectively kill tumor cells. INTASYL has also demonstrated enhancement adoptive cell therapy. Notably, INTASYL is a self-delivering RNAi technology focused on immuno-oncology therapeutics without the need for formulation enhancements or manipulations to reach its target. Phio’s lead clinical program, PH-762, is an INTASYL compound that silences PD-1. PH-762 is a potential non-surgical treatment for skin cancers. The on-going Phase 1b trial (NCT# 06014086) received FDA clearance for an Investigational New Drug Application to evaluate PH-762 in the treatment of cutaneous SCC, melanoma and Merkel cell carcinoma in second quarter of 2023. For additional information, visit the Company’s website, www.phiopharma.com . Forward-Looking Statements This press release contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. Forward-looking statements can be identified by words such as “intends,” “believes,” “anticipates,” “indicates,” “plans,” “expects,” “suggests,” “may,” “would,” “should,” “potential,” “designed to,” “will,” “ongoing,” “estimate,” “forecast,” “target,” “predict,” “could” and similar references, although not all forward-looking statements contain these words. Examples of forward-looking statements contained in this press release include, among others, the ability of the Company to consummation of the offering, the satisfaction of the closing conditions of the offering and the use of proceeds therefrom, the possibility that our INTASYL® siRNA gene silencing technology will make the body’s immune cells more effective in killing cancer cells and statements regarding our commercial and clinical strategy, development plans and timelines and other future events. These statements are based only on our current beliefs, expectations and assumptions and are subject to inherent uncertainties, risks and changes in circumstances that are difficult to predict and many of which are outside of our control. Our actual results may differ materially from those indicated in the forward-looking statements as a result of a number of important factors, including, but not limited to, the impact to our business and operations by inflationary pressures, rising interest rates, recession fears, the development of our product candidates, results from our preclinical and clinical activities, our ability to execute on business strategies, our ability to develop our product candidates with collaboration partners, and the success of any such collaborations, the timeline and duration for advancing our product candidates into clinical development, the timing or likelihood of regulatory filings and approvals, the success of our efforts to commercialize our product candidates if approved, our ability to manufacture and supply our product candidates for clinical activities, and for commercial use if approved, the scope of protection we are able to establish and maintain for intellectual property rights covering our technology platform, our ability to obtain future financing, market and other conditions and those identified in our Annual Report on Form 10-K and subsequent Quarterly Reports on Form 10-Q under the caption “Risk Factors” and in other filings the Company periodically makes with the SEC. Readers are urged to review these risk factors and to not act in reliance on any forward-looking statements, as actual results may differ from those contemplated by our forward-looking statements. Phio does not undertake to update forward-looking statements to reflect a change in its views, events or circumstances that occur after the date of this release, except as required by law. To view the source version of this press release, please visit https://www.newsfilecorp.com/release/234533 #distro
The Mexico-set musical drama, about a feared drug lord who undergoes gender-affirming surgery, clinched the best film, director, screenwriter and actress prizes, in addition to its previously announced editing prize. Receiving the first prize of the evening, for European director, Audiard said he had prepared no fewer than three speeches. “I was being very optimistic,” he joked. Accepting the best director award he quoted British paediatrician and psychoanalyst Donald Winnicott’s famous phrase: “It is a joy to be hidden, and disaster not to be found,” and thanked the Academy for recognising him. Later in the evening, receiving the screenwriting prize, Audiard dedicated it to French-Danish actor Niels Arestrup, who he directed in and and who died last week. Additionally, ’s breakout star Karla Sofía Gascón won the best actress prize. “Thank you to the best European director for making the best European actress – thank you Jacques,” said Gascón. One of the big surprises of the evening was newcomer Abou Sangare’s best actor win for his part in in a category that also included hotly tipped names such as Ralph Fiennes for and Daniel Craig for Sangare plays a Guinean asylum seeker who tries to work the gig economy on the streets of Paris in the drama which premiered in Cannes’ Certain Regard, winning the jury prize and earning Sangare a best actor award. Political ceremony A politically charged awards ceremony began with an introduction by Oscar winning actress Juliette Binoche, the new president of the European Film Academy. She said that film is a way to enlighten each other and open up to differences. “The European Film Academy is a great symbol to that dream. Our artistic reunion includes Palestine, Israel, Ukraine, Russia, Turkey, Georgia and many other countries. We are here to share our work with care and respect.” The documentary prize was won by about the Israeli demolition of villages in Masafer Yatta in the West Bank. It is the latest in a string of wins for Berlinale premiere which in the past weeks has also won documentary prizes at the New York Film Critics Circle and the Gothams. Two of its co-directors - Israeli journalist Yuval Abraham and Palestinian activist Basel Adra – accepted the reward remotely by video feed. Adra said it was very hard to celebrate the award at a time when “the occupation is committing a genocide against my people,” while Abraham said ethnic cleansing was being carried out against the Palestinian people in Gaza. Addressing European governments, Abraham said: “It’s not enough to demand a ceasefire. A ceasefire needs to be imposed.” As they finished their acceptance speech, a shout of “Free Palestine” rang out in the auditorium. There was an added political dimension to the documentary prize category, which was presented by Belarusian filmmaker and activist Andrei Gnyot. The European Film Academy campaigned this year to prevent him being extradited back to Belarus. “Due to open letters from European film community I was freed. You cannot imagine my gratitude...you have to understand that you saved my life, that is why I am here now.” The animation prize was won by director Gints Zilbalodis’s It is the latest prize for the Latvian film, which is building real awards momentum. Earlier this week it also won best animation at the New York Film Critics Circle. debuted in Cannes’ Un Certain Regard and went on to screen at Annecy, where it won four prizes including the competition jury and audience award. During the ceremony, Italian actress and filmmaker Isabella Rossellini received the European Achievement In World Cinema award, while German filmmaker Wim Wenders was awarded the European Lifetime Achievement prize, and Macedonian producer Labina Mitovska was honoured with the Eurimages International Co-Production award. Kôji Yakusho, who starred as a public toilet cleaner in Wenders’ recent hit film appeared in a video tribute to the director. Branding a toilet brush, he joked that he would clean Wenders’ toilet to celebrate his victory. In his acceptance speech, Wenders urged the audience to serve the European film community. “Europe needs you, the film community, to produce to a more positive and emotional image of a continent that is a little bit lost in translation, because too many people think of it as an economic or financial community. But it is an emotional unity. It gives us strength and we should give it strength.” This year’s ceremony took place at the KKL concert hall Lucerne, Switzerland and was hosted by Swiss voiceover actor Fernando Tiberini. Switzerland is a four-language country and Tiberini billed this year’s EFAs as multilingual awards show. He encouraged winners to speak in own language when accepting awards; their words were interpreted live in English. “Come up on stage and be yourselves,” he said. Winners in boldUTSA earns 117-58 win against Southwestern AdventistStrinova - Official Release Date TrailerNEW YORK (AP) — Stocks are closing lower as Wall Street ends a holiday-shortened week on a down note. The S&P 500 fell 1.1% Friday and the the Dow Jones Industrial Average lost 333 points, or 0.8%. The Nasdaq composite dropped 1.5%. The “Magnificent 7” stocks weighed on the market, led by declines in Nvidia, Tesla and Microsoft. Even with the loss, the S&P 500 had a modest gain for the week and is still headed for its second consecutive annual gain of more than 20%, the first time that has happened since 1997-1998. The yield on the 10-year Treasury rose to 4.62%. THIS IS A BREAKING NEWS UPDATE. AP’s earlier story follows below. NEW YORK (AP) — Technology stocks are dragging down the market Friday as Wall Street closes out a holiday-shortened week. The S&P 500 fell 1.3%, with more than 90% of stocks in the benchmark index losing ground. The benchmark index was managing to hold onto a modest gain for the week. The Dow Jones Industrial Average fell 418 points, or 1%, to 42,878 as of 1:43 p.m. Eastern time. The Nasdaq composite fell 1.8%. Technology stocks were the biggest weight on the market Friday. Semiconductor giant Nvidia slumped 2.7%. Its enormous valuation gives it an outsize influence on indexes. Other Big Tech stocks losing ground included Microsoft, with a 2% decline. A wide range of retailers also fell. Amazon fell 1.9% and Best Buy slipped 1.8%. The sector is being closely watched for clues on how it performed during the holiday shopping season. Energy stocks held up better than the rest of the market, with a loss of just 0.1% as crude oil prices rose 1.4%. The S&P 500 gained nearly 3% over a 3-day stretch before breaking for the Christmas holiday. On Thursday, the index posted a small decline. “There's just some uncertainty over this relief rally we've witnessed since last week,” said Adam Turnquist, chief technical strategist for LPL Financial. Despite Friday's drop, the market is moving closer to another standout annual finish . The S&P 500 is on track for a gain of around 25% in 2024. That would mark a second consecutive yearly gain of more than 20%, the first time that has happened since 1997-1998. The gains have been driven partly by upbeat economic data showing that consumers continued spending and the labor market remained strong. Inflation, while still high, has also been steadily easing. A report on Friday showed that sales and inventory estimates for the wholesales trade industry fell 0.2% in November, following a slight gain in October. That weaker-than-expected report follows an update on the labor market Thursday that showed unemployment benefits held steady last week. The stream of upbeat economic data and easing inflation helped prompt a reversal in the Federal Reserve's interest rate policy this year. Expectations for interest rate cuts also helped drive market gains. The central bank recently delivered its third cut to interest rates in 2024. Even though Inflation has come closer to the central bank's target of 2%, it remains stubbornly above that mark and worries about it heating up again have tempered the forecast for more interest rate cuts. Inflation concerns have added to uncertainties heading into 2025, which include the labor market’s path ahead and shifting economic policies under incoming President Donald Trump. Worries have risen that Trump’s preference for tariffs and other policies could lead to higher inflation , a bigger U.S. government debt and difficulties for global trade. Amedisys rose 4.7% after the home health care and hospice services provider agreed to extend the deadline for its sale to UnitedHealth Group. The Justice Department had sued to block the $3.3 billion deal, citing concerns he combination would hinder access to home health and hospice services in the U.S. The move to extend the deadline comes ahead of an expected shift in regulatory policy under Trump. The incoming administration is expected to have a more permissive approach to dealmaking and is less likely to raise antitrust concerns. In Asia, Japan’s benchmark index surged as the yen remained weak against the dollar. Stocks in South Korea fell after the main opposition party voted to impeach the country’s acting leader. Markets in Europe gained ground. Bond yields held relatively steady. The yield on the 10-year Treasury rose to 4.61% from 4.59% late Thursday. The yield on the two-year Treasury slipped to 4.31% from 4.33% late Thursday. Wall Street will have more economic updates to look forward to next week, including reports on pending home sales and home prices. There will also be reports on U.S. construction spending and snapshots of manufacturing activity.
Police suspect a man on the run from south-west England is hiding out in Wales. Aston Campbell, a 35-year-old from Bristol, is wanted on recall to prison and is throught to be in Newport . Gwent Police has shared a social media appeal from Gloucestershire Constabulary stating: "We issued an appeal to locate him on November 26, and we have now renewed our appeal in a bid to find him. Campbell is described as being black, 6ft in height, of a slim build, with black hair in an afro. He also has a tattoo of a bird on his left arm and symbols tattooed on his left hand. "Our officers have completed a number of enquiries to find Campbell but have been unable to locate him so far. If you see him, do not approach him but call police on 999." Anyone with information on Campbell's whereabouts is asked to complete this online form , quoting incident 314 of November 25. For the latest court reports, sign up to our crime newsletter here Join the WalesOnline WhatsApp community WalesOnline has launched a new breaking news and top stories WhatsApp community. From the biggest court stories to the latest traffic updates, weather warnings and breaking news, it's a simple way to stay up to date with what's happening in Wales. Want to join? All you have to do is click on this link , select 'Join Community' and you're in. We will not spam your feed with constant messages, but you will receive updates from us daily. If for some reason you decide you no longer want to be in our community, you can leave by clicking on the name at the top of your screen and clicking 'Exit Group'. We occasionally treat our community members to special offers, promotions, and adverts from us and our partners. You can read our Privacy Notice here. Join our WhatsApp community hereColby Rogers shines as Memphis rolls past Ole Miss
Shocking Boxing Day stampede at store after owner invites people to 'steal'— The George Washington Hotel invites you to bid farewell to 2024 with not one, not two, but five New Year’s Eve Babys. The Babys, one of the top rock and power-pop bands of the late 1970s and early 1980s, will be playing in the downtown hotel’s ballroom on Dec. 31 to close out the GW’s year-long 100th anniversary celebration. “We’ll play all of the hits,” said the band’s lead singer and bassist, John Bisaha. “And we’ll do a lot of rock and B-side stuff. We rock a lot harder than The Babys did back in the day. ... We’re looking to get everyone on their feet and having a good time.” Suzi Smith, general manager of the GW, said booking The Babys for a New Year’s Eve gig in Winchester was serendipitous. Here’s how it happened. The GW has put on a concert series this year featuring Orleans, John Ford Coley and Firefall as part of the hotel’s 100th anniversary celebration. Smith said the hotel had been hoping to line up a fourth musical act for New Year’s Eve but did not have any luck until Firefall played there in October. That’s when Smith and hotel co-owner Glen Burke met Bisaha, who sings lead and plays bass for both The Babys and Firefall. Burke asked if The Babys would be willing to close out the GW’s 100th anniversary celebration on Dec. 31, and Bisaha was quick to agree because of how much he enjoyed the friendliness and history of Winchester. “We’re actually going to be staying a few days after this gig,” Bisaha said. “That’s how much we love Winchester, love the people there.” In an interview this week, Bisaha said he became the frontman of two bands because The Babys and Firefall had the same booking agency and often shared billing at concerts. In July 2022, Firefall bassist and vocalist Mark Andes retired from touring and recommended that Bisaha take his place. Firefall leader Jock Bartley agreed and Bisaha joined the lineup. “I’m playing in two different styles,” said Bisaha, noting that Firefall and The Babys come from the same era but play different types of music. While Firefall plays country-rock similar to acts like The Eagles and Jackson Browne, The Babys is more straightforward rock with heavy elements of pop. The Babys formed in 1975 in London with the lineup of John Waite (bass/vocals), Michael Corby (keyboards/guitar), Tony Brock (drums) and Wally Stocker (guitar). After recording three albums, Corby left the group and was replaced by two Americans: Jonathan Cain (keyboards) and Ricky Phillips (bass). The band enjoyed tremendous success, churning out five albums featuring Top 40 hits including “Isn’t It Time,” “Back on My Feet Again,” “Turn and Walk Away” and “Every Time I Think of You.” But after Waite suffered a leg injury in December 1980 that forced the cancellation of The Babys’ concert tour, the group disbanded in January 1981. Cain joined the band Journey in time to co-write and record the album “Escape,” which yielded several hit singles including the still-popular anthem “Don’t Stop Believin’.” Waite launched a solo career, scoring a No. 1 hit in 1984 with the song “Missing You.” From 1981 until 2012, The Babys were defunct. That changed when original members Brock and Stocker decided to reform the band with the blessings of Waite, Cain and Phillips. After an extensive talent search — “It was pretty vigorous,” Bisaha said — Brock and Stocker hired Bisaha to play bass and sing lead vocals. When they met his wife, Holly, they were so impressed by her singing talents that they hired her as a Babette (the band’s affectionate term for its female background singers) along with Elisa Chadbourne. “The Babettes got the gig before I did,” John Bisaha said with a laugh. “I had to still work (audition) for another month.” The band’s new lineup of John Bisaha, Stocker, Brock, Joey Sykes (rhythm guitar) and Walter Ino (keyboards) have toured and recorded extensively over the past decade with Babettes Holly Bisaha and Chadbourne. However, Stocker decided to step back from touring last year and the GW’s ballroom is relatively small, so only five Babys will perform in Winchester next week: John Bisaha, Holly Bisaha, Brock, Sykes and Ino. “We’ve got four of us dudes and Holly making the music of seven,” John Bisaha said, noting that his wife is key to the group’s sound because she’s the one who sings the female lead in what is arguably The Babys’ most popular song, “Every Time I Think of You.” John Bisaha said the band’s current concert performances sometimes eclipse the classic shows put on by The Babys’ original lineup. “It’s because of technology and — this is the key thing — taking care of your body and being in the moment,” Bisaha said. “Back then, being in the moment meant, how trashed can I be when I’m on stage? It was a lot different in the ’70s than it is in the 2020s.” The Babys will close out the GW’s 100th anniversary concert series on Dec. 31 from 8:30 to 10 p.m., meaning concert goers will still be able to attend New Year’s Eve parties to welcome the arrival of 2025. Tickets are $100 each and are available online via Eventbrite at . “They’ll get a nice high-energy show and have a good time,” John Bisaha said. “And we’re going to see what kind of New Year’s Eve elements we can bring into the mix to add a little flavor. I’m not gonna promise to be a New Year’s Eve baby and jump out in a diaper or anything like that, but we’ll see what we can do.”
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Jamiat Ulema-e-Islam (JUI-F) chief Maulana Fazlur Rehman has said that he has not received any formal message from Pakistan Tehreek-e-Insaf (PTI) founder Imran Khan for a meeting, stressing that he will carefully consider such a request if it is made. "I have not received any formal message from the PTI founder for a meeting," he said while talking to journalists who showed up at his residence to inquire after his health on Saturday. "I will make a decision after thorough contemplation, if the PTI founder expresses a desire to meet me." The JUI-F chief's remarks come more than a month after he denied media reports that claimed that the Maulana Fazlur Rehman-led party decided to meet the incarcerated PTI founder in Rawalpindi’s Adiala Jail. The media reports had claimed that JUI-F Senator Kamran Murtaza, after receiving the court’s nod, would meet Khan in the Rawalpindi jail. During the meeting, the two opposition parties would discuss a strategy to give a tough time to the Prime Minister Shehbaz Sharif-led federal government, the reports added. However, a JUI-F spokesperson called such media reports “rumours”, saying Senator Murtaza was not given any special task in this regard. “There should be a fair trial in cases filed against the PTI founder. We are and will remain in contact with the PTI as an opposition party," the party's spokesperson noted. Earlier today, Fazl reiterated his complaint about the February 8 elections, saying that his religio-political party was not provided with a level playing field in the election. “Some individuals allowed themselves to be used, whereas we refused to be part of such manipulation,” he remarked. Replying to a question, Fazl highlighted his party's commitment to institutional strength over personal interests in the 26th Amendment. He also criticised uncalled-for interference in previously settled matters regarding the registration of seminaries. However, he affirmed progress on the issue. Turning to security concerns, Fazl expressed alarm over the situation in Khyber Pakhtunkhwa, noting, “There is no writ of the government in the province as districts like Dera Ismail Khan, Bannu, and Tank are under the control of terrorists.” He further revealed that courts and government offices in Tank have been relocated to Dera Ismail Khan due to security challenges. Responding to a question about his party's relations with the PTI, he underscored: “We maintain a working relationship with the Imran-founded party at the federal level. But, we have different stance on provincial matters.”Interim Results from STOMP Study of SIGA's Tecovirimat in Treatment of Mpox AnnouncedAdversaries open third front against India
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