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An investigation has been launched into the disappearance of an Israeli-Moldovan dual citizen who lives in the United Arab Emirates and has been missing since Thursday, the Israeli prime minister's office said on Saturday. It said in a statement that authorities in the Gulf country had opened the investigation based on information that the man's disappearance was related to "a terrorist incident", without providing further details. The missing man was identified as Zvi Kogan, a representative in the UAE of Chabad, an Orthodox Jewish group that has chapters around the world and seeks to build links with non-affiliated and secular Jews or other sects of Judaism. The UAE's state news agency later said the interior ministry was searching for the missing man and investigating his disappearance, without mentioning his Israeli citizenship. Chabad UAE declined to comment. The group's branch in the UAE supports thousands of Jewish visitors and residents in the country, providing religious and social services to Jewish people across the Gulf region, according to its website. The UAE became the most prominent Arab state in 30 years to establish formal ties with Israel under a U.S.-brokered agreement in 2020, dubbed the Abraham Accords. It has maintained the relationship during the Israel-Hamas war in Gaza. REUTERS Join ST's Telegram channel and get the latest breaking news delivered to you. Read 3 articles and stand to win rewards Spin the wheel now
Quick Links Testing the US Navy's Super Hornets The Rhino's latest Block What are the new features? GE's engine enhancements Fear the Rhino's weaponry Block II vs Block III The future of the Boeing Super Hornets Boeing announced that the F/A-18 Super Hornet upgrades include a large area display and advanced Tactical Targeting Network Technology for more powerful computing, with a Distributed Targeting Processor-Networked DTP-N that reduces pilot workload by allowing evidence-based information on the new display. This open mission systems processor has the power to compute algorithms to manage any complex air combat. “These first deliveries of Block III SLM jets are a major milestone in our continued efforts to ensure capability, reliability, availability and maintainability of the Super Hornet aircraft,” said Capt. Michael Burks, program manager for the F/A-18 and EA-18G Program Office . The aerospace giant has received the F/A-18 Block II for Service Life Modernization SLM , which will be upgraded to the new Block III configuration, adding an extra 4,000 flight hours. Boeing successfully delivered the first two upgraded fighters from its two facilities in St. Louis and San Antonio to the US Navy on June 27, 2024. On March 2024, The US Navy awarded Boeing a $1.3 billion contract for 17 F/A-18 Super Hornets and a technical data package. The contract was awarded to help address the strike fighter shortfall, with final delivery expected in spring 2027. The Navy also plans to convert 550 other Super Hornets to the Block III standard. Boosting US air capabilities in the region. Testing the US Navy's Super Hornets Boeing delivered its first two Block III Super Hornets to the US Navy for flight testing in June 2020 . It marked a shift from purchasing new jets from Boeing to focusing on developing the fourth-generation fighter jet. The Block III model is more "networked and survivable" than the Block II design, with five major design features: An advanced cockpit system that combines original displays into a glass touchscreen. Conformal fuel tanks for fuel-carrying and tanking capacity. A prominent flight service life. Radar cross-section improvements. An advanced networking infrastructure to aid the pilot in decision-making. The Navy announced that the funds for a multiyear purchase of Super Hornets from 2022 will be redirected to developing Air Dominance and other aviation wholeness investments. The decision to truncate the Super Hornet production line is about freeing up the Boeing production line and workforce to focus on the program, which would maintain the right balance of Super Hornets versus F-35 Fighters in the carrier air wing and deliver greater capability and service life on converted jets. “The Super Hornet remains a predominant aircraft in the carrier air wing and will continue to provide significant combat capability into the 2040s,” said Rear Adm. John Lemmon, Program Executive Officer for Tactical Aircraft Programs. The Rhino's latest Block The Super Hornet, available in two models - the single-seat E and two-seat F - performs various tactical missions, including air superiority, precision-guided strikes, fighter escort, close air support, suppression of enemy defenses, maritime strike, reconnaissance, forward air control, and tanker missions. Its new strengthened airframe will extend the service life to more than 10,000 flight hours. What are the new features? The advanced Rhino offers operational advantages against technologically advanced systems and adversaries. Its advanced processing, networking, survivability, and range/payload capabilities provide an operational advantage. The Block III aircraft features an improved cockpit with a 10 in × 19 in (25 cm × 48 cm) large touchscreen display, updated integration, and targeting networks. It provides pilots with extraordinary payload flexibility. Its advanced data link and threat detection enable better data processing and transmission, operating in lightning and thunderstorm weather and cold temperatures. It also features an advanced cockpit system and long-wave Infrared Search & Track for long-range threat detection. Over 800 Super Hornets produced with over 10 million flight hours, tested and proven for regular upgrades, offer low procurement and total life cycle costs of approximately $19K USD per flight hour. GE's engine enhancements The modern General Electric afterburning turbofan features an enhanced performance engine (EPE) that boosts the power output of the F414-GE-400 by 20%. The F414 Enhanced Engine offers enhanced performance, survivability, and payload for the twin-engined F-18 Block III. The F414 can be retrofitted for improved component capability and reduced ownership costs. The US Navy has relied on the F414 engine for over 30 years, providing over 5 million engine flight hours and unrestricted operability. The F414 is also a potential powerplant for emerging platforms like the Korean KF-X KAI KF-21 Boramae, Indian Medium Combat Aircraft HAL Tejas Mk2, and Swedish Saab JAS 39E/F Gripen. Fear the Rhino's weaponry The aircraft features a next-generation cockpit, an internal infrared search and track system, and conformal fuel tanks. It also has an enclosed weapons pod (EWP) and a new missile warning system. It offers a day/night strike with precision-guided weapons, featuring 11 hardpoints distributed at the wingtips, under the wing, and under the fuselage. The new weapons pod can carry missiles and bombs with reduced radar lock risks. It can use shorter-range Sidewinder air-to-air missiles, AMRAAM, Joint Standoff Weapon, Small Diameter Bomb, and Mk-84 general-purpose bombs. Like Block II, it has a 20mm M61 rotary cannon and can carry the AGM-65 Maverick missile, AGM-84 Harpoon ship-killing missile, and AGM-88 HARM anti-radar missile. Air-to-air missiles Air-to-surface missiles AIM-7 Sparrow AGM-158 JASSM AIM-9 Sidewinder AGM-158C LRASM AIM-120 AMRAAM AGM-84H/K SLAM-ER AIM-260 JATM AGM-154 JSOW AIM-174B AGM-88 HARM AGM-84 Harpoon AGM-65E/F Maverick The jet can also carry the ADM-141A/B TALD decoy missile and the Raytheon AN/ALE-50 towed decoy system, an electronic countermeasure tool designed to protect US military aircraft from radar-guided missiles to confuse and saturate enemy air defenses, allowing attacking aircraft and weapons a higher probability of penetrating the target. This heavy lifting, which exceeds 17,000 lb (7711 kg), is useful for fleet defense missions, early warning missions, electronic surveillance, and tankers. Block II vs Block III The fourth-generation fighter, a 20% larger and 7,000 lbs heavier aircraft than the prior Hornets, offers increased capability and functionality. Its additional hardpoints and powerful engines enable it to carry more ordnance and expand its range. With most internal improvements, one visible change is incorporating conformal fuel tanks, which attach directly to the fuselage, reducing drag. Another advantage of the Block IIIs is increased lifespan, improving flight time between training and deployments. Feature Block II Block III Data Link Multi-Functional Information Distribution System MIDS Tactical Targeting Network Technology TTNT Conformal Fuel Tanks N/A Available, increasing range Mission Computer Advanced Mission Computer AMC Distributed Targeting Processor-Networked DTP-N, 17 times more powerful Service Life 6,000 Flying hours 10,000 Flying hours The future of the Boeing Super Hornets Boeing and Northrop Grumman financed the Advanced Super Hornet program, which features a 50% reduction in frontal radar cross-section, conformal fuel tanks CFT, and an enclosed weapons pod. The new block could be integrated into the EA-18 Growler to reduce underwing space and lower drag margin for the Next Generation Jammer . The F/A-18E/F mission allows combatant commanders to conduct offensive and defensive air combat missions, attack ground targets using the US inventory of precision and non-precision weapon stores, provide in-flight refueling for other tactical aircraft, and offer organic tactical reconnaissance capabilities. Australia and Kuwait have acquired earlier Super Hornets, but Australia is transitioning to F-35A fighter jets, and Kuwait has ordered Eurofighter Typhoon jets. Canada has halted the Boeing F/A-18 Block III Super Hornet from its Future Fighter Capability Project FFCP competition. The decision was made after rigorous evaluations of proposals based on capability, cost, and economic benefits. The US Navy's Hornet has an exceptional legacy of performance that has made it the jet of choice for the flat-top fleet in the modern era.
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CM Mamata Banerjee In Sandeshkhali TodayCOLUMBUS, Ohio (AP) — A fight broke out at midfield after Michigan stunned No. 2 Ohio State 13-10 on Saturday as Wolverines players attempted to plant their flag and were met by Buckeyes who confronted them. Police had to use pepper spray to break up the players, who threw punches and shoves in the melee that overshadowed the rivalry game. Ohio State police said in a statement “multiple officers representing Ohio and Michigan deployed pepper spray.” Ohio State police will investigate the fight, according to the statement. After the Ohio State players confronted their bitter rivals at midfield, defensive end Jack Sawyer grabbed the top of the Wolverines' flag and ripped it off the pole as the brawl moved toward the Michigan bench. Eventually, police officers rushed into the ugly scene. Ohio State coach Ryan Day said he understood the actions of his players. “There are some prideful guys on our team who weren't going to sit back and let that happen,” Day said. The two Ohio State players made available after the game brushed off questions about it. Michigan running back Kalel Mullings, who rushed for 116 yards and a touchdown, didn't like how the Buckeyes players involved themselves in the Wolverines' postgame celebration. He called it “classless.” “For such a great game, you hate to see stuff like that after the game," he said in an on-field interview with Fox Sports. “It’s just bad for the sport, bad for college football. But at the end of the day, you know some people got to — they got to learn how to lose, man. ... We had 60 minutes, we had four quarters, to do all that fighting.” Michigan coach Sherrone Moore said everybody needs to do better. “So much emotions on both sides," he said. "Rivalry games get heated, especially this one. It’s the biggest one in the country, so we got to handle that better.” Get poll alerts and updates on the AP Top 25 throughout the season. Sign up here . AP college football: https://apnews.com/hub/ap-top-25-college-football-poll and https://apnews.com/hub/college-football
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Trastuzumab rezetecan is under clinical development by and currently in Phase I for Head And Neck Cancer. According to GlobalData, Phase I drugs for Head And Neck Cancer have a 75% phase transition success rate (PTSR) indication benchmark for progressing into Phase II. GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval. Trastuzumab rezetecan overview Trastuzumab rezetecan (SHRA-1811) is under development for the treatment of HER2 expressing or mutated advanced malignant solid tumor, human epidermal growth factor receptor 2 positive breast cancer (HER2+ breast cancer), HER2-negative Advanced Breast Cancer, metastatic breast cancer, metastatic biliary cancer (BTC), advanced non-small cell lung cancer, metastatic colorectal cancer, gastric cancer, cervical cancer, recurrent ovarian cancer and endometrial cancer and adenocarcinoma of the gastroesophageal junction. It comprises of the anti-HER2 antibody trastuzumab, a cleavable linker, and the topoisomerase I inhibitor payload SHR169265. It is administered by intravenous and parenteral route. The drug candidate is an antibody drug conjugate which acts by targeting cells expressing tyrosine kinase type cell surface receptor HER2. Jiangsu Hengrui Medicine overview (Jiangsu Hengrui) is a biopharmaceutical company that focuses on the research, development, manufacture, and distribution of novel pharmaceutical products. Its product portfolio includes anti-tumor drugs, surgical drugs, contrast agents, angiomyocardiac drugs, and antibiotics. The company is also developing pipeline products for the treatment of cancer, Crohn’s disease, anemia, diabetes, atopic dermatitis, chronic bone disease, blood pressure, and hypercholesterolemia. Jiangsu Hengrui has R&D facilities in China, the US, and Japan. The company offers products through its sales and distribution network in China, the US, Japan, Germany Switzerland and Australia. Jiangsu Hengrui is headquartered in Lianyungang, Jiangsu Province, China. For a complete picture of Trastuzumab rezetecan’s drug-specific PTSR and LoA scores, This content was updated on 12 April 2024 From Blending expert knowledge with cutting-edge technology, GlobalData’s unrivalled proprietary data will enable you to decode what’s happening in your market. You can make better informed decisions and gain a future-proof advantage over your competitors. , the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article. GlobalData’s Likelihood of Approval analytics tool dynamically assesses and predicts how likely a drug will move to the next stage in clinical development (PTSR), as well as how likely the drug will be approved (LoA). This is based on a combination of machine learning and a proprietary algorithm to process data points from various databases found on GlobalData’s .AP Business SummaryBrief at 6:40 p.m. EST
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“I am hopeful that with the majorities now that we will be able to get across the finish line,” Scanlan told The Center Square on Thursday, speaking of more legislation on the way to protect women's spaces. “Obviously, this goes beyond sports ... So ideally, I think that the biggest thing would be to federally pass something that says this is what a woman is.” Scanlan a day earlier was part of a panel where U.S. Sen. Roger Marshall, R-Kan., announced that Republicans plan to soon introduce legislation to “protect children from transgender medical procedures.” A report from the advocacy group Do No Harm released four weeks before Election Day included documented evidence of such activity being performed on a 7-year-old . “We’ll be introducing the STOP Act soon,” said Marshall . “We are going to use the Commerce Act to punish people who perform any type of surgery, or who use any type of medications on minors.” STOP is an acronym for Safeguarding the Overall Protection of Minors. The panel said that the legislation is an important and necessary step to protect children. Scanlan and Marshall, a host with the American Principles Project, were on the panel alongside U.S. Sen. Tommy Tuberville, R-Ala.; U.S. Rep. Mary Miller, R-Ill.; Terry Schilling, president of the American Principles Project; and Sarah Parshall Perry, senior legal fellow at the Heritage Foundation. “We all know by now that so-called gender affirming care is anything but caring,” Tuberville said. “It is pure insanity and has caused irreversible damage to countless children. This isn’t about politics, this is about good and evil.” Scanlan is an ambassador for Independent Women's Voice and a former collegiate swimmer at the University of Pennsylvania. Swimming for the Quakers, she and teammates endured being not only on the same team but in the same locker room as a swimmer who for the first three years swam on the men's team. “I was a swimmer at the University of Pennsylvania and the administration, the university and the NCAA said , ‘Here's a man who wants to swim on your team, please accept him,’” she explained during the panel. “This entire situation really made all female athletes feel isolated and alone, and like they know where to go.” Scanlan said that it wasn’t just competing that isolated the female athletes. “Eighteen times per week, my teammates and I were forced to undress next to a 6-foot-4, fully-intact male,” Scanlan said. “As a female athlete, this was just something I couldn't even imagine. It was something I never imagined would happen to me when I went off to college.” The STOP Act is one of a few beginnings. U.S. Rep. Nancy Mace, R-S.C., has proposed legislation seeking to protect women’s spaces on all federal property nationwide. This would include bathrooms, locker rooms and prisons. Scanlan said this shows that public opinion is on the side of her and the panel. “This is really the first time we're seeing more of these people in power stepping up and actually doing the right thing and saying enough is enough” she said. “Now, we are looking at entire teams that are feeling empowered to be able to boycott ... or object to competing against males. It's widespread.” A notable case of that is San Jose State, where Blaire Fleming's participation has led to seven opponents forfeiting rather than playing a women's team that includes a man saying he is a woman. Tuberville and Marshall emphasized they believe the majority of Americans would agree with the proposed legislation. "The American people are sick of this nonsense," Tuberville said . "It’s time we restore some sanity and get common sense back in this country." Scanlan said that while she supports the national legislation Republicans are considering, it is important for states to also continue to pass legislation. “I always remind people who are really excited about having a presidency that we don't know what might happen in four years," she said. "So, of course, it's also important to codify this in states. We are going to continue our efforts. There's still a lot of work to be done, and I don't really see it as a win until we've finished this on the state level.”