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A new way of treating serious asthma and chronic obstructive pulmonary disease (COPD) attacks could be a “game-changer” and is the first leap in treatment for 50 years, researchers say. Offering patients an injection is more effective than the current care of steroid tablets and cuts the need for further treatment by 30%, according to a study. Benralizumab is a monoclonal antibody that targets specific white blood cells, called eosinophils, to reduce lung inflammation. It is currently used as a repeat treatment for severe asthma at a low dose, but a new clinical trial has found that a higher single dose can be very effective if injected at the time of a flare-up. The findings, published in the Lancet Respiratory Medicine, included 158 people who needed medical attention in A&E for their asthma or COPD attack (COPD is a group of lung conditions that cause breathing difficulties). Patients were given a quick blood test to see what type of attack they were having, with those suffering an “eosinophilic exacerbation” involving eosinophils (a type of white blood cell) being suitable for treatment. Around 50% of asthma attacks are eosinophilic exacerbations, as are 30% of COPD ones, according to the scientists. The clinical trial, led by King’s College London and carried out at Oxford University Hospitals NHS Foundation Trust and Guy’s and St Thomas’ NHS Foundation Trust, saw patients randomly split into three groups. One group received the benralizumab injection and dummy tablets, another received standard care (prednisolone steroids 30mg daily for five days) and a dummy injection, and the third group received both the benralizumab injection and steroids. After 28 days, respiratory symptoms of cough, wheeze, breathlessness and sputum were found to be better in people on benralizumab. And after 90 days, there were four times fewer people in the benralizumab group who failed treatment compared with those receiving steroids. Treatment with the benralizumab injection also took longer to fail, meaning fewer visits to a GP or hospital for patients, researchers said. Furthermore, people also reported a better quality of life on the new regime. Scientists at King’s said steroids can have severe side-effects such as increasing the risk of diabetes and osteoporosis, meaning switching to benralizumab could provide huge benefits. Lead investigator Professor Mona Bafadhel, from King’s, said: “This could be a game-changer for people with asthma and COPD. “Treatment for asthma and COPD exacerbations have not changed in 50 years, despite causing 3.8 million deaths worldwide a year combined. “Benralizumab is a safe and effective drug already used to manage severe asthma. “We’ve used the drug in a different way – at the point of an exacerbation – to show that it’s more effective than steroid tablets, which is the only treatment currently available.” Researchers said benralizumab could also potentially be administered safely at home or in a GP practice, as well as in A&E. First author Dr Sanjay Ramakrishnan, clinical senior lecturer at the University of Western Australia, said: “Our study shows massive promise for asthma and COPD treatment. “COPD is the third leading cause of death worldwide but treatment for the condition is stuck in the 20th century. “We need to provide these patients with life-saving options before their time runs out.” Dr Samantha Walker, director of research and innovation at Asthma and Lung UK, welcomed the findings but said: “It’s appalling that this is the first new treatment for those suffering from asthma and COPD attacks in 50 years, indicating how desperately underfunded lung health research is.” AstraZeneca provided the drug for the study and funded the research, but had no input into trial design, delivery, analysis or interpretation.
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Morgan Rogers looked to have given Emery’s side another famous win when he slammed a loose ball home in stoppage time, but referee Jesus Gil Manzano ruled Diego Carlos to have fouled Juve goalkeeper Michele Di Gregorio and the goal was chalked off. Contact seemed minimal but VAR did not intervene and Villa had to settle for a point in a 0-0 draw. “With the last action, it is the interpretation of the referee,” the Spaniard said. “In England, 80 per cent of those is given a goal and it’s not a foul. It’s very soft. “But in Europe, it could be a foul. We have to accept. “Everybody will know, in England the interpretation is different. The England referees, when actions like that the interpretation is a clear no foul but in Europe that interpretation is different. “They have to be working to get the same decision when some action like that is coming. I don’t know exactly why but we knew before in the Premier League that it is different. A very controversial finish at Villa Park 😲 Morgan Rogers' late goal is ruled out for a foul on Juventus goalkeeper Michele Di Gregorio and the match ends 0-0 ❌ 📺 @tntsports & @discoveryplusUK pic.twitter.com/MyYL5Vdy3r — Football on TNT Sports (@footballontnt) November 27, 2024 “In Europe for example we are not doing a block like in England and we are not doing in front of the goalkeeper in offensive corners the same situations like in England. “When the action happened, I was thinking here in Europe it’s a foul. In England not, but in Europe I have to accept it. “At first, I thought the referee gave us a goal. In cases like that, it’s confusing because he has to wait for VAR. I don’t know what happened but I think so (the referee changed his mind with VAR).” It was a disappointment for Villa, who remain unbeaten at home in their debut Champions League campaign and are still in contention to qualify automatically for the last 16. “We were playing a favourite to be in the top eight and usually a contender to win this competition,” Emery added. “We are a team who for a long time didn’t play in Europe and the Champions League and this year is very important. “We wanted to play competitive and we are in the right way. Today to get one point is very good, we wanted to win but wanted to avoid some mistakes we made in previous games. “We have 10 points and we’re happy.” Before the game Emery called Juventus one of the “best teams in the world, historically and now”, but this was an Italian side down to the bare bones. Only 14 outfield players made the trip from Turin, with striker Dusan Vlahovic among those who stayed behind. Juve boss Thiago Motta, whose side are 19th but still in contention to reach the top eight, said: “There’s just three games left to qualify. The next home against Man City, then Brugge, then Benfica. “One at a time, as we always did with the goal to qualify for the next round. “In the end we will try and reach our goal which is to go to the next round.”BEIRUT (AP) — Syria's de facto leader said Sunday it could take up to four years to hold elections in Syria, and that he plans to dissolve his Islamist group that led the country's insurgency at an anticipated national dialogue summit for the country. Ahmad al-Sharaa, who leads Hayat Tahrir al-Sham, the group leading the new authority in Syria, made the remarks in an interview with Saudi television network Al-Arabiyya. It comes almost a month after a lightning insurgency led by HTS overthrew President Bashar Assad's decades-long rule, ending the country's uprising-turned civil war that started back in 2011. Al-Sharaa said it would take time to hold elections because of the need for Syria's different forces to hold political dialogue and rewrite the country's constitution following five decades of the Assad dynasty's dictatorial rule. Also, the war-torn country's battered infrastructure needs to be reconstructed, he said. “The chance we have today doesn’t come every 5 or 10 years,” said al-Sharaa, formerly known as Abu Mohammed al-Golani. “We want the constitution to last for the longest time possible.” Al-Sharaa is Syria's de facto leader until March 1, when Syria's different factions are set to hold a political dialogue to determine the country's political future and establish a transitional government that brings the divided country together. There, he said, HTS will dissolve after years of being the country's most dominant rebel group that held a strategic enclave in the country's northwest. Earlier, an Israeli airstrike in the outskirts of Damascus on Sunday killed 11 people, according to a war monitor, as Israel continues to target Syrian weapons and military infrastructure even after the ouster of Assad. The Britain-based Syrian Observatory for Human Rights said the airstrike targeted a weapons depot that belonged to Assad’s forces near the industrial town of Adra, northeast of the capital. The observatory said at least 11 people, mostly civilians, were killed. The Israeli military did not comment on the airstrike Sunday. Israel, which has launched hundreds of airstrikes over Syria since the country's uprising turned-civil war broke out in 2011, rarely acknowledges them. It says its targets are Iran-backed groups that backed Assad. Unlike his criticism of key Assad ally Iran, al-Sharaa hoped to maintain “strategic relations” with Russia, whose air force played a critical role in keeping Assad in power for over a decade during the conflict. Moscow has a strategic airbase in Syria. The HTS leader also said negotiations are ongoing with the Kurdish-led Syrian Democratic Forces in northeastern Syria, and hopes that their armed forces will integrate with the Syrian security agencies. The Kurdish-led group is Washington’s key ally in Syria, where it is heavily involved in targeting sleeper cells belonging to the extremist Islamic State group. Turkish-backed Syrian rebels have been clashing with the SDF even after the insurgency, taking the key city of Manbij, as Ankara hopes to create a buffer zone near its border in northern Syria. The rebels attacked near the strategic northern border town of Kobani, while the SDF shared a video of a rocket attack that destroyed what it said was a radar system south of the city of Manbij. In other developments: — Syrian state-run media said a mass grave was found near the third largest city of Homs. SANA said civil defense workers were sent to to the site in al-Kabo, one of many suspected mass graves where tens of thousands of Syrians are believed to have been buried during a brutal crackdown under Assad and his network of security agencies. — An Egyptian activist wanted by Cairo on charges of incitement to violence and terrorism, Abdulrahman al-Qardawi, was detained by Lebanese security forces after crossing the porous border from Syria, according to two judicial and one security officials who spoke on condition of anonymity because they were not authorized to to talk to the press. Al-Qardawi is an Egyptian activist residing in Turkey and an outspoken critic of Egypt's government. He had reportedly visited Syria to join celebrations after Assad's downfall. His late father, Youssef al-Qaradawi, was a top and controversial Egyptian cleric revered by the outlawed Muslim Brotherhood. He had lived in exile in Qatar for decades. — Lebanese security forces apprehended an armed group in the northern city of Tripoli that kidnapped a group of 26 Syrians who were recently smuggled into Lebanon, two Lebanese security officials said on condition of anonymity because they were not authorized to share the information with the media. The Syrians included five women and seven children, and security officials are working to return them to Syria.BEIRUT (AP) — Syria's de facto leader said Sunday it could take up to four years to hold elections in Syria, and that he plans to dissolve his Islamist group that led the country's insurgency at an anticipated national dialogue summit for the country. Ahmad al-Sharaa, who leads Hayat Tahrir al-Sham, the group leading the new authority in Syria, made the remarks in an interview with Saudi television network Al-Arabiyya. It comes almost a month after a lightning insurgency led by HTS overthrew President Bashar Assad's decades-long rule, ending the country's uprising-turned civil war that started back in 2011. Al-Sharaa said it would take time to hold elections because of the need for Syria's different forces to hold political dialogue and rewrite the country's constitution following five decades of the Assad dynasty's dictatorial rule. Also, the war-torn country's battered infrastructure needs to be reconstructed, he said. “The chance we have today doesn’t come every 5 or 10 years,” said al-Sharaa, formerly known as Abu Mohammed al-Golani. “We want the constitution to last for the longest time possible.” Al-Sharaa is Syria's de facto leader until March 1, when Syria's different factions are set to hold a political dialogue to determine the country's political future and establish a transitional government that brings the divided country together. There, he said, HTS will dissolve after years of being the country's most dominant rebel group that held a strategic enclave in the country's northwest. Earlier, an Israeli airstrike in the outskirts of Damascus on Sunday killed 11 people, according to a war monitor, as Syrian weapons and military infrastructure even after the ouster of Assad. The Britain-based Syrian Observatory for Human Rights said the airstrike targeted a weapons depot that belonged to Assad’s forces near the industrial town of Adra, northeast of the capital. The observatory said at least 11 people, mostly civilians, were killed. The Israeli military did not comment on the airstrike Sunday. Israel, which has launched hundreds of airstrikes over since the country's uprising turned-civil war broke out in 2011, rarely acknowledges them. It says its targets are Iran-backed groups that backed Assad. Unlike his criticism of key Assad ally Iran, al-Sharaa hoped to maintain “strategic relations” with Russia, whose air force played a critical role in keeping Assad in power for over a decade during the conflict. Moscow has a strategic airbase in Syria. The HTS leader also said negotiations are ongoing with the Kurdish-led Syrian Democratic Forces in northeastern Syria, and hopes that their armed forces will integrate with the Syrian security agencies. The Kurdish-led group is Washington’s key ally in Syria, where it is heavily involved in targeting sleeper cells belonging to the extremist Islamic State group. Turkish-backed Syrian rebels have been clashing with the SDF even after the insurgency, taking the key city of Manbij, as Ankara hopes to create a buffer zone near its border in northern Syria. The rebels attacked near the strategic northern border town of Kobani, while the SDF shared a video of a rocket attack that destroyed what it said was a radar system south of the city of Manbij. In other developments: — Syrian state-run media said a was found near the third largest city of Homs. SANA said civil defense workers were sent to to the site in al-Kabo, one of many suspected mass graves where tens of thousands of Syrians are believed to have been buried during a brutal crackdown under Assad and his network of security agencies. — An Egyptian activist wanted by Cairo on charges of incitement to violence and terrorism, Abdulrahman al-Qardawi, was detained by Lebanese security forces after crossing the porous border from Syria, according to two judicial and one security officials who spoke on condition of anonymity because they were not authorized to to talk to the press. Al-Qardawi is an Egyptian activist residing in Turkey and an outspoken critic of Egypt's government. He had reportedly visited Syria to join celebrations after Assad's downfall. His late father, was a top and controversial Egyptian cleric revered by the outlawed Muslim Brotherhood. He had lived in exile in Qatar for decades. — Lebanese security forces apprehended an armed group in the northern city of Tripoli that kidnapped a group of 26 Syrians who were recently smuggled into Lebanon, two Lebanese security officials said on condition of anonymity because they were not authorized to share the information with the media. The Syrians included five women and seven children, and security officials are working to return them to Syria. Kareem Chehayeb, The Associated Press
Elon Musk has backed allegations of wrongdoing in the death of Suchir Balaji, a 26-year-old tech researcher of Indian descent and ex-OpenAI worker. Poornima Ramarao, Balaji’s mother, has requested an FBI investigation, claiming that evidence disputes the San Francisco Police Department's determination of suicide. Who Is Poornima Ramarao?Poornima Ramarao is the mother of Suchir Balaji. Ramarao has asked for a federal inquiry into her son's death. Her concerns were backed by Musk, the owner of Tesla. He commented under Ramarao's post, "This doesn't seem like a suicide." Ramarao claimed there were inconsistencies in the case via a succession of public statements. She emphasized results from a personal autopsy and inquiry, asserting that Balaji’s apartment exhibited indications of a struggle. Writing on social media, Ramarao stated, “Suchir’s apartment was ransacked. There were blood spots in the bathroom. It looks like he was hit. This is a cold-blooded murder misclassified as suicide.” Ramarao further accused local authorities of interference, adding, “Lobbying in SF city doesn’t stop us from getting justice. We demand an FBI investigation.” Musk Joins the Chorus for AnswersBillionaire entrepreneur Elon Musk voiced his agreement, tweeting, “This doesn’t seem like a suicide.” His remark heightened public interest in the case and encouraged Ramarao to seek further assistance. As reported by The Times of India, Musk had earlier condemned the ethics of OpenAI, fueling speculation around Balaji’s demise. Ethical Concerns and Rising MomentumBalaji, a renowned figure in technology, had openly denounced AI practices in recent months. In October, he discussed with The New York Times, expressing worries about copyright infringements by major AI firms. His critiques positioned him at the center of a legal conflict, with the publication referencing him in a prominent copyright lawsuit against OpenAI. In August, Balaji stepped down from OpenAI, allegedly due to ethical disputes. His sudden passing, just days after he turned 26, has sparked demands for openness. Leading advocates for AI ethics are calling for enhanced safeguards for whistleblowers and independent inquiries into the matter. Police Stand By Suicide ConclusionBalaji was discovered deceased in his San Francisco apartment on November 26. Surveillance video revealed he was by himself in the hours before his passing. The San Francisco Police Department ruled the death a suicide, noting insufficient evidence to suggest foul play. Get Latest News Live on Times Now along with Breaking News and Top Headlines from US News, World and around the world.Larson Financial Group LLC lowered its holdings in VanEck Gold Miners ETF ( NYSEARCA:GDX – Free Report ) by 65.8% during the 3rd quarter, according to the company in its most recent disclosure with the Securities & Exchange Commission. The firm owned 1,509 shares of the exchange traded fund’s stock after selling 2,905 shares during the period. Larson Financial Group LLC’s holdings in VanEck Gold Miners ETF were worth $60,000 at the end of the most recent quarter. A number of other institutional investors also recently modified their holdings of the business. Beacon Capital Management LLC raised its holdings in VanEck Gold Miners ETF by 202.4% during the 2nd quarter. Beacon Capital Management LLC now owns 747 shares of the exchange traded fund’s stock valued at $25,000 after acquiring an additional 500 shares during the period. LRI Investments LLC bought a new stake in shares of VanEck Gold Miners ETF during the 1st quarter valued at $28,000. Cedar Wealth Management LLC raised its stake in shares of VanEck Gold Miners ETF by 63.4% during the 2nd quarter. Cedar Wealth Management LLC now owns 874 shares of the exchange traded fund’s stock valued at $30,000 after purchasing an additional 339 shares during the period. Aptus Capital Advisors LLC lifted its holdings in VanEck Gold Miners ETF by 53.0% during the 3rd quarter. Aptus Capital Advisors LLC now owns 950 shares of the exchange traded fund’s stock worth $38,000 after purchasing an additional 329 shares in the last quarter. Finally, Eagle Bay Advisors LLC boosted its stake in VanEck Gold Miners ETF by 95.8% in the 2nd quarter. Eagle Bay Advisors LLC now owns 1,175 shares of the exchange traded fund’s stock worth $40,000 after purchasing an additional 575 shares during the period. VanEck Gold Miners ETF Stock Up 0.6 % Shares of GDX opened at $37.66 on Friday. VanEck Gold Miners ETF has a twelve month low of $25.67 and a twelve month high of $44.22. The stock has a market cap of $15.05 billion, a PE ratio of 28.03 and a beta of 0.85. The business’s 50-day moving average price is $39.66 and its 200-day moving average price is $37.59. VanEck Gold Miners ETF Company Profile The Fund seeks to match as closely as possible the price and yield performance of the AMEX Gold Miners Index. The Fund, utilizing a passive or indexing investment approach, attempts to approximate the investment performance of the Index by investing in a portfolio of stocks that generally replicate the Index. See Also Want to see what other hedge funds are holding GDX? Visit HoldingsChannel.com to get the latest 13F filings and insider trades for VanEck Gold Miners ETF ( NYSEARCA:GDX – Free Report ). Receive News & Ratings for VanEck Gold Miners ETF Daily - Enter your email address below to receive a concise daily summary of the latest news and analysts' ratings for VanEck Gold Miners ETF and related companies with MarketBeat.com's FREE daily email newsletter .